Each of these products is formulated to support digestive health in a different way. AxisTM TreBiotic is a standalone product that does not require any additional supplementation in order to obtain its maximum benefits. However, there is no harm in incorporating Probiotic in an AxisTM TreBiotic regimen. They contain different strains, so taking these together may help increase microbiome diversity. Digestive Enzymes aids the gut by helping to break down foods. For anyone planning to use all three products, we suggest taking the AxisTM Trebiotic and Probiotic either at breakfast or lunch and taking the Digestive Enzymes with dinner.