TreBiotic is a standalone product that does not require any additional supplementation in order to obtain its maximum benefits. However, there is no harm in incorporating Probiotic and/or Digestive Enzymes in a TreBiotic regimen. Modere Probiotic contains different strains than the NeuroFlora™ Probiotic Complex that is in TreBiotic, so taking these together may help increase microbiome diversity. The GOS prebiotic that pairs perfectly with NeuroFlora in TreBiotic may also help encourage the growth of other beneficial bacteria in the gut, including those contained in Modere Probiotic. Digestive Enzymes aids the gut by helping to break down foods. For anyone planning to use all three products, we suggest taking the Trebiotic and Probiotic either at breakfast or lunch and taking the Digestive Enzymes with dinner.